Structural mobility and transformations in globular proteins

Operads of higher transformations for globular sets and for higher magmas

‎In this article we discuss examples of fractal $omega$-operads‎. ‎Thus we show that there is an $omega$-operadic approach to explain existence of‎ ‎the globular set of globular setsfootnote{Globular sets are also called $omega$-graphs by the French School.}‎, ‎the reflexive globular set of reflexive globular sets‎, ‎the $omega$-magma of $omega$-magmas‎, ‎and also the reflexive $omega$-magma ...

Families and the structural relatedness among globular proteins.

Protein structures come in families. Are families "closely knit" or "loosely knit" entities? We describe a measure of relatedness among polymer conformations. Based on weighted distance maps, this measure differs from existing measures mainly in two respects: (1) it is computationally fast, and (2) it can compare any two proteins, regardless of their relative chain lengths or degree of similari...

Structural hot spots for the solubility of globular proteins.

Natural selection shapes protein solubility to physiological requirements and recombinant applications that require higher protein concentrations are often problematic. This raises the question whether the solubility of natural protein sequences can be improved. We here show an anti-correlation between the number of aggregation prone regions (APRs) in a protein sequence and its solubility, sugg...

Structural features that predict real-value fluctuations of globular proteins.

It is crucial to consider dynamics for understanding the biological function of proteins. We used a large number of molecular dynamics (MD) trajectories of nonhomologous proteins as references and examined static structural features of proteins that are most relevant to fluctuations. We examined correlation of individual structural features with fluctuations and further investigated effective c...

Structural Change and Men’s Work Lives: Transformations in Social Stratification and Occupational Mobility in Monterrey, Mexico